I'm with Murray, San Francisco good fun, Las Vegas very artificial and really not to my taste.Plenty of other lovely places nearby (well, in relative terms), my favourites being Death Valley and Bryce Canyon.
Love Vegas and San Francisco but lurve Vegas so much now been 7 times! I did a driving holiday started off in San Fran stopping at loads of please including Yosemite, Santa Barbara. Desert Springs, Death Valley to name a few and finally Vegas.