In low doses, nutmeg produces no noticeable physiological or neurological response. Large doses of 60 g (~12 teaspoons) or more are dangerous, potentially inducing convulsions, palpitations, nausea, eventual dehydration, and generalized body pain[1] In amounts of 10-40 g (~4-8 teaspoons) it is a mild to medium hallucinogen, producing visual distortions and a distinct euphoria. According to some, the effects have a striking similarity to cannabis intoxication, except with a longer duration, and more side effects. Nutmeg contains myristicin, a weak monoamine oxidase inhibitor.
Comparisons between nutmeg intoxication and MDMA have been made, however this remains speculative.[2]. This has recently been disproved by the 2006 paper "Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry" by Hans Maurer et al at University of Saarland. However, use of nutmeg as a recreational drug is unpopular due to its unpleasant taste and its side effects, including dizziness, flushes, dry mouth, accelerated heartbeat, temporary constipation, difficulty in urination, nausea, and panic. A user will not experience a peak until approximately six hours after ingestion, and effects can linger for up to three days afterwards.
A risk in any large-quantity (over 25 g, ~5 teaspoons) ingestion of nutmeg is the onset of 'nutmeg poisoning', an acute psychiatric disorder marked by thought disorder, a sense of impending doom/death, and agitation. Some cases have resulted in hospitalization.
Fatalities occur with lower doses with children. An 8-year-old boy who consumed just two nutmegs fell into a coma, only to die 20 hours later.[3]
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