The answer is usually in the water, but you say you have tested it! did you test it yourself? or did you take it to be tested? some of them you can buy are not that accurate. It is heart breaking to lose them when your trying your best to rectify it. If your advised medication as not worked maybe its something else. Its costly to lose koi as they are so expensive depending on size and colours as you know. It may be worth you taking one to a vet type place that deals with fish also, expensive maybe, but long term not as costly as losing them.There are so many things that can kill koi as they are so vulnerabe to all sorts. Do you filter by bio, or ultra violet? I would recommend ultra for koi.