Effect Of Aspirin/ibuphrophen

[nohorn]

Which has the more negative effect on your kidney and liver? Could one be considered more safe than the other? The question is for the effect on adults rather than children. Just wondering

[Dee Sa]

many years ago my hubby got an abscess on his kidney from taking Ibuphrophen on a regular basis he was peeing blood, he was hospitalised for a week[ we lived in Dubai then] and was told never to take again, he never did. Twenty years later he died of renal complications, but we could not find out if the two were linked as he was also a bad diabetic.

[Sqad]

In normal and recommended doses, neither of them will have any deleterious effect on the kidney.

[mrs_overall]

Sqad, can I add to your answer....."unless you already have any underlying problem"

[Sqad]

Dee.sa.......I note your post with interest.
There is evidence to suggest that treating kidney infections with antibiotics AND ibuprofen, reduces the long term effects of kidney damage...............quite the opposite to Ibuprofen damaging the kidney.

Interesting though as you quite rightly say, his kidney damage may well have been due to other factors...e.g diabetes.

[Sqad]

Maybe! maybe....I think that you are referring to IBS........?

[mrs_overall]

Sqad, a renal patient I know well was telling me that renal patients are instructed never to take Ibuprofen

[Sqad]

Mrs_O I know! I know! It is a matter of sorting the wheat from the chaff here and like all contentious points in medicine one can find a report or study in the literature to support your point of view.

If you have normal kidney function, then normal doses of Ibuprofen even for long term use will not damage the kidney.
N
Now....the use of Ibuprofen in a patient with acute or chronic kidney failure is a different ball game.............

[mrs_overall]

hands sqad a rose for agreeing with me
lol

[Sqad]

Don"t associate me with that bloke DT.....................bloody rose........................;-)

[pixie373]

They are both quite harsh on the stomach, it's paracetamol that's processed by the liver. I don't know of any effects on the kidneys with any of them.

[Khandro]

I was informed there is a mis-match between Ibuprofen and blood pressure reducing drugs such a Micardis of which I take a low dose of 20mg per day. When I occasionally want relief from headache etc I now take Paracetamol.

[slaney]

It's worth remembering that the renal toxicity of Ibuprofen is dose related.
At a dose of 1,200 mg/day the relative risk (RR) of renal failure is 0.94 in the over 65s, at doses of 1,200-2,400 mg/day the RR is 1.85, and at doses over 2,400 mg/day the RR is 2.3.
So the greater the dose the greater the risk. This is why the BNF (British National Formulary) recommends a dose up to 1,200 mg/day for this age group - there will be clinical exception to this of course.

[Sqad]

slaney

\\\It's worth remembering that the renal toxicity of Ibuprofen is dose related.\\\

Indeed......but also duration related.

\\\and at doses over 2,400 mg/day the RR is 2.3. \\ but for what length of time. It would seem that those doses for a long term e.g R.A may well be correct, but for short time use e.g influenza, then the RR would not apply.

[jomifl]

So, ibupofren can cause kidney damage but can aspirin? as originally asked.

[Sqad]

jomifl.....simple answer.......Yes......they both can.

[jomifl]

http://www.kidney.org/atoz/content/painMeds_Analgesics.cfm

From the above
10 or more tablets per day (3000 mgm. or 3 gm.) of aspirin can cause temporary or permanent kidney damage.

Aspirin occurs naturally in the body but in lower concentrations that those produced by even low level doses, apparently.

[jomifl]

Thanks sqad :-)

[slaney]

Indeed Sqad, duration is also a risk - all those patients were taking prescribed Ibuprofen for various lengths of time.
Anecdotally ( you'll like this!) I have seen two patients in their 70s with previously normal renal function go into renal failure after a week and ten days of Ibuprofen respectively.
I suppose the important thing is to take the lowest effective dose for the shortest period of time.
There are obviously some people who should never take Ibuprofen at all.
http://www.nhs.uk/Conditions/Painkillers-ibuprofen/Pages/Special-considerations.aspx

[Sqad]

slaney...;-)

\\all those patients were taking prescribed Ibuprofen for various lengths of time.\\

Who said? where does it say that ? Have you just made it up ;-) ?

Millions of people take Ibuprofen annually for short terms.....migraine, flu, musculo skeletal injuries...............they are not included in any series.

As for the NHS link, one must ask, after reading it, who can take ibuprofen? Does common sense come in to the equation? See the post of Khandro above.......he really believes, after being told, that a 600mgm tablet of Ibuprofen perhaps for a headache will upset his hypotensive regime.

\\\\\I suppose the important thing is to take the lowest effective dose for the shortest period of time. \\\ Exactly that is if one is prepared to wait and see which IS the lowest effect dose.

[slaney]

And what about my anecdote Sqad? :)

I'll try and go though the full text of the paper on Medline and get an answer to that.
Information on the timing, duration, and dose of prescription was given but is not in the abstract but it will take time I haven't got at the moment.

Anyway, you are a believer in the power of Ibuprofen, and I doubt anything I say will alter that. I have my reservations.