I've tried Lipobind, no difference. I've also been on Reductil, lost 10 pounds in about 3 weeks, but wouldn't really recommend, as it does have side effects, particularly increasing Blood Pressure and can cause heart palpitations.
Orlistat works by removing fat from the body, this also works, but the major side effect is that fat will randomly leak from the anus without warning.
What worked best for me was a healthy, calorie controlled diet and loads of exercise, especially weights.