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thanks Lankeela - I have had products from Doreen Paige already. And strangely enough she has been prescribed optimmune. Her tear duct production was very low, the one did not even register on the scale, and the minimum reading is apparently 5 - normal reading is 10, but apparently most dogs read around 15-20. After putting Optimmune in twice daily her reading went up to 17 in one eye, and 10 in the other, but I have tried not to use it every day now and reduced it to every other day, and when I took her for a check up on Monday, the readings were down to 10 in both eyes again. However, I 'think' the pigmentation is coming back a little, as the corners of the skin around her eyes are almost back to black - so the pigmentation loss in her eyes could be due to dry eye, and nothing to do with her nose and lips. However, she now has a reddy/pinkish area on her nose again, so I cant win! I am now convinced the latter problem is related to a horrible habit that bitches have, especially when they are in season, and she is due, so just trying to stop her putting her nose where it shouldnt be! Strange one though, you will have to ask around and let me know if anyone has any bright ideas!