I have been on these for a year 300mg twice a day with cocodomol antidepressants ,diazepam , tramadol all the maximum doses. I absoloutley hate lyrica. they help pain yeah for trapped nerves but then you start to get twitchesso sre weight gaient from 9 stone to 12 stone in 6 months, also I am seriously addicted to them. I have try to come of them cold turkey which is absoloutley terrible DO NOT DO IT. u get cold sweats, aches and pains, twitches and feel like complete and utter crap. I am seeing another doctor to try to wean off these again, I am actually in more pain now with the weight gain causing my back and knees to be very painful. I will have to cut down gradually and do it properly this time but I hate the thought of coming off them, they make u feel spaced out a lot which I actually like to get away from reality as I suffer severe depression, pls pls if u can avoid going on a higher dose, do, or not go on them at all. I wish to god I was never put on these. they are ruining my life as my personality changes and ive nearly lost my husband and best friends over these especially but many more mixed.