Be very careful Sandmaster.
There are several Regions with no regional franchisee holder (including London - bizarre and worrying is that), and then within the established Regions, there are area slots. Think very carefully about the area you are considering in terms of the business development opportunity in that area.
I know nothing about Fastway's business model; others I have seen work well for those who have a reasobable prospect of developing new business from established businesses in the area. There is a payment to the pick-up provider and another for the drop. What happens is the originator gets lots of parcels at customer pick-up, but the drop gets a mish-mash of parcels to deliver all over the place - to customer addresses - either busines or household. So if one runs a rural area, you get lots of the latter, little of the former.
Also check out how they link the Regional Depots together? - no mention of this in the website.
Many of these 'National' carriers run a central hub, often in the Stoke area, where transport from the out-of-Region parcels get sent for an 'exchange' - this is the way the whole country is covered.