Disregarding your greedy relatives, there is a way that you could lose it all before your estate even gets to your daughters or any other inheritors.
If you own your property as "Joints Tenants" then both husband and wife own 100% of the property. If one of you dies then the ownership automatically passes to the remaining spouse who will still own 100% of the property.
Now, assuming that the remaining spouse gets an illness in later years and needs 24 hour care then they will finish up in a care home. With sufficient money available they could go in to a private home which you pay for until the money runs out and then the local council carries on paying for the upkeep.
If you die before the money runs out then you can leave the balance in your Will to your children.
However, If the Council decide you need the services of a care home and arrange it, it is possible that the council may claim the home and sell it to pay for your upkeep. Under those circumstances your inheritors have very little to inherit.
However, if you change the ownership of the property to Tenants-in-Common (via the Land Registry) then you and your wife will then own 50% of the house each and you can then both make Wills out leaving your 50% of the property to the children.
When the first spouse dies, the remaining spouse still has 50% of the property and the kids now own 50% shared between them.
If the surviving spouse later on needs 24 hour care then then council cannot claim the property to pay for the upkeep as it is not fully owned by you (the kids own 50%) and they would not be able to claim or even sell half a house.
You could still sell the house and use your 50% to pay for a private care home if you wish but at least the children get some of your inheritance.
Your solicitor can arrange all this or at least inform you of the pros and cons of the Tenants-in-Common arrangement.
Obviously, you have to put in the Will that the remaining spouse has the permanent right to stay in the house as long as they wish otherwise some kids might demand that they sell their share of the property and put you out on the street! Not good, but needs to be covered.