Look ...
You have to decide how much 'spring' there is in the floor .. and the total spans involved. Chipboard panels will be springy .. solid timber is ok. Neither are likely to be OK on their own.
If the floor springs, the tile grouts (and sometimes the tiles) will crack soon enough. If normal boards, I would probably ply it, using C/S screws, then tile on top. This will obviously raise the level by as much as 18mm with tiles, so you will always have a thresh-hold/door/skirting problem.