Since the power-assistance for the brakes relies on the vacuum in the inlet manifold and you appear to be lacking power-assistance, together with the lumpy running, it implies to me that you have a leak in the inlet manifold. This can be anything from a bad gasket to a crack in the manifold.
You may be able to hear a sucking noise from the manifold if you listen carefully. I seem to remember there was an old trick of using an unlit butane torch to blow gas around the inlet; if the engine note changed it showed there was a leak as the gas was sucked into the engine instead of air. Perhaps someone else will confirm/deny this memory.