Have always been a fan of this show (and its American spin-off) and wish it would return - but without Clive Anderson who ruins it. Can't honestly think of a single reason why it could not return.
It was scripted to a certain degree, loved the british version better, some of the americans are so not funny, and there blinkin shouting and whoop whoop audiences, i dont know who could replace clive any ideas???
I think you'd just end up with the usual round of comedians who we see often enough on panel game shows.
WLIA was brilliant for its time as it gave direct access to comedians doing the comedy club circuit/jongleurs etc. Nowadays we see them all the time and many are not that funny, take Mock The Week for example, only Frankie Boyle is funny.