I'm unsure exactly what you are asking. You treat friends as friends don't you ? Was there something specific you wanted advice on ?
I'm assuming the covered in angels person (?) is not an issue to you. As for the other friend, well she obviously has issues that she'll need to sort out and accept for herself over time. You can be there with a sympathetic ear when she needs you, if you like. Meanwhile if she feels the need to tell everyone she is attracted to the wrong sex then maybe just let her. Others will probably just sympathise or tolerate or simply feel sorry that she seems to have the need to tell everyone; as if others cared to know.