I liked this post by the taliesin to try and picture just how many combinations we are talking about:
Start a timer that will count down the number of seconds from 52! to 0.
Start by picking your favorite spot on the equator. You're going to walk around the world along the equator, but take a very leisurely pace of one step every billion years. The equatorial circumference of the Earth is 40,075,017 meters.
After you complete your round the world trip, remove one drop of water from the Pacific Ocean. Now do the same thing again: walk around the world at one billion years per step, removing one drop of water from the Pacific Ocean each time you circle the globe. The Pacific Ocean contains 707.6 million cubic kilometers of water. Continue until the ocean is empty.
When it is, take one sheet of paper and place it flat on the ground. Now, fill the ocean back up and start the entire process all over again, adding a sheet of paper to the stack each time you've emptied the ocean.
Do this until the stack of paper reaches from the Earth to the Sun. Take a glance at the timer, you will see that the three left-most digits haven't even changed. You still have 8.063e67 more seconds to go. 1 Astronomical Unit, the distance from the Earth to the Sun, is defined as 149,597,870.691 kilometers. So, take the stack of papers down and do it all over again. One thousand times more. Unfortunately, that still won't do it. There are still more than 5.385e67 seconds remaining. You're just about a third of the way done.
Of course, in reality none of this could ever happen. The Pacific Ocean will boil off as the Sun becomes a red giant before you could even take your fifth step in your first trek around the world. Somewhat more of an obstacle, however, is the fact that all the stars in the universe will eventually burn out leaving space a dark, ever-expanding void inhabited by a few scattered elementary particles drifting a tiny fraction of a degree above absolute zero. The exact details are still a bit fuzzy, but according to some reckonings of The Reckoning, all this could happen before you would've had a chance to reduce the vast Pacific by the amount of a few backyard swimming pools.
http://czep.net/weblog/52cards.html
Now if that doesn't strike people as being impossible, I give up.