No, not if I don't let it get to that stage. They're a very clean animal really, they have an area in their hutch where they do their business. I put newspaper down and then cover with sawdust, every night when I get home I roll up the paper and put in a carrier bag, tie it and put in the wheelie bin (no, where you wheelie bin?), spray some anti bug spray in the aera before putting down more paper and sawdust.
One per week I clean out the whole hutch, all the straw etc., wipe it down with disinfectant and every other week I take the floors out (double decker hutch) and give them a good scrub under the shower.
Even to me that sounds time consuming, but it's not, the daily job just takes a few minutes, the weekly job takes about 15 minutes and the fortnightly job takes about half an hour or so.