Genes within the human genome - rogue genes

[Willo89]

Do all humans carry the same basic set of genes?

There are currently discussions regarding the genes in the human genome, varying from 20,000 to 100,000 - http://www.ornl.gov/sci/techresources/Human_Ge nome/faq/genenumber.shtml

Irrespective of the actual number, does this mean that all humans have whatever set of genes that are eventually determined, or do humans have a subset of the total genes found?

I think that all humans share this as yet undetermined number of total genes and that the concept of 'rogue genes' relates to specific groupings of alleles.

See http://www.dailymail.co.uk/health/article-4693 57/Rogue-genes-heart-attack-risk-smoker.html

The important distinction that I am trying to understand is this �

1. Do humans all share the same genes, and all differences relating to genetic makeup relate to different combinations of alleles within this fixed set of genes. (I am fully aware of the effects of environment and epigenesis on the phenotype � this question relates solely to the genotype)

OR

2. Do some humans have genes that do not exist in other humans, and so reap the benefits, disabilities because of those genes?

Regards

Willo89

[rov1200]

Your second link gives you the answer to your first question. ie

Up to three-quarters of the population carry at least one of the six genes, raising the risk of having a heart attack by up to 40 per cent

[Willo89]

Rov1200 - but do they actually mean different genes or do they mean genes that everyone has but that carry a fatal allele?

[rov1200]

Much study has been undertaken into BBRAC1 or breast cancer gene. Every woman has this gene but only some go onto develop breast cancer. Scientists have discovered up to 1000 mutations of this gene which can result in causing the disease.

http://ghr.nlm.nih.gov/gene=brca1

[rov1200]

Theres a mutation in my gene above it should read BRCA1