Kaflooey?

[crispynugget]

What does it mean?

[Azimov]

Can you use it in a sentence?
I think we need a context to try to work out the meaning!

[Quizmonster]

If you put the word - spelt with a single 'f' as you have - into the Google search slot, you will be offered over 20, 000 web-pages on the subject. Perhaps one of these will help.
With a double 'f', only three and one of these suggests it means something like 'disordered' as in: "If you do such and such on your computer, the document will go all kafflooey." So akew, skew-whiff, lopsided, crooked etc may be what you are looking for.
Over to you.

[dawnI]

Also means to destroy something