20 Across :- Outsize partner of Maria gets openings in Italy (5) O?T?A. It looks like OSTIA (town/city in Italy). I get OS (Outsize) and TIA (partner of Maria as in Tia Maria), but what has "gets openings" got to do with it?
ostium
noun
ANATOMY•ZOOLOGY
an opening into a vessel or cavity of the body.
ZOOLOGY
each of a number of pores in the wall of a sponge, through which water is drawn in.
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