Ah, we were put on this earth to suffer - hang on, maybe you weren't MartianAlien!
I agree LordB's comments were unnecessarily negative. Some of us enjoy tedious numberwork (here speaks someone with a better hit rate on the numericals than the others) - but I know what he means - once the numbers start going in, the thing will be finished if you are careful: I scribbled a 37 instead of 47 at one point (or some such) which threw out the next few calculations. If I hadn't noticed as soon as I did, I may have had real trouble backtracking, I might've lost the will to continue.
It is one of those where getting started is the main hurdle. I had the same experience as Midaz. - couple of hours before I put the first definite digit in the grid. Then I took a break and came back to it fresh.
I didn't use any Euclidean calculator but a spreadsheet took a bit of hammering.
Martian, your 3 observations are not particularly relevant.
1 & 2. F's glut and C's dearth of intercept factors is by chance - I didn't take any note of it.
3. Missing "i": There are 22 primes between 2 and 79 inclusive - they are indicated by lowercase a through w though it is not just i that is not mentioned j,o and q aren't in any clue either.
There is nothing to say all 22 are used and even if they are used they might never be in an entry that intercepts with another that uses it.
I approached it by listing all the prime factor letters for each "spoke" and "circular" entry that we know of from the clues. Then thought about those with the most factors, especially where they intercept another with a lot of factors.
Anyway glad I got there in the end as I just ran out of beer.
Pip pip!