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Independent 7226 (12 Dec)

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Mikejas | 23:57 Sun 13th Dec 2009 | Crosswords
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6a Instrument, one deployed in a theatre (6) P?P???
12a Doctor replaces hint of cure with new prescribed course (4) L???
21a Jabbed without resistance in one of the 15? ?R?? ( I've got 15d as SPECIFICS)
8d Almost ready in operating scene for 19 (7) ??S???E (I've got 19 as HEART)
22d Appearance in London hospital by Speaker ??I?E
This has been a bad week for the Indy and me!
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22d Guise (guys)
6a PUPPET
21a DRUG DUG = " jabbed" with R inserted)
8d ESSENCE Anagram of SCENE containing SE ( SET = "almost ready" truncated)
12a Can only think of LINE = prescribed course
12a LANE [prescribed course]

doctor = lace
replaces hint of cure with new = replace the C with an N
Question Author
Thought about Guys but couldn't see it. Was distracted by the capital S in Speaker. Similarly came up with ESSENCE and PUPPET but could work them through.
Thanks again, for the usual great service, people

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