1d Dutch alto saxophonist first brought to public attention in the video for the 1989 Prince song partym Partyman,(5-6) (c?n??-d??f??) 14d Muslim legal expert empowered to give rulings on religious matters.(5) (?u??i) 18d Branch of medicine concerned with the study and treatment of blood.(11) (??e??t??o?y) 24d Crystalline derivative of the amino acid cysteine found in mammalian bile and nerve tissue,important in the metabolism of fats.(7) (t?u?i?e) 25d City of wester Saudi Arabia whose Mosqueof the Prophet houses the tomb of Muhammad.(6) (?e?i?a) 26d Difference between the bid and offer price of shares or securities.(6) (?p?e?d)