Monday Prize Crossword No. 14,548

[grandilo]

Some help with the following, please:
ACROSS:
4 Before starting treatment mention new remedy(8): ?????A??
6 Organ movement(10)
21 Indisposed to be criticized? ( 3,4 ) : R??????
DOWN:
5 Formally dressed Italians lacking a change ( 2,5 ): ??T????
18 Around noon, top fighter pilots attempt descent(8): ???M?T?Y

Many thanks for any help!

[sandyRoe]

21 run down

[slaney]

21 Run down

[scorpiojo]

21 run down

[scorpiojo]

5 in tails

[slaney]

18 A(n)ces try

[sandyRoe]

6 transplant?

[scorpiojo]

What letters do you have now for 4a) please?

[grandilo]

4a now reads: ?I?T?E??

Thanks for helping!

[Mamyalynne]

Ointment

[bibblebub]

ointment

first letter of 'treatment' after anagram of 'mention'

[Sipowicz]

Mention.

[Mamyalynne]

anagram of - mention and (T)reatment

[Sipowicz]

? meant ointment!

[grandilo]

Thanks to all of you...I just saw Ointment!

[grandilo]

The last two:
ACROSS
16 Excitement created by the coming down of an astronaut ( 6 )
S?L???
DOWN:
17 A good man to break the latest news( 4,5 ) : ??O???E?S

Thanks again for the hints!

[Mamyalynne]

16 Splash

[Mamyalynne]

17 Stop Press

[Mamyalynne]

oh, you only wanted hints?

[grandilo]

I thank you all for the invaluable help...I realize now that each crossword setter has his own inimitable style of word play which I have to get used to. I am getting good practice here! Thanks to all again!