5d: 16th century family of French printers who brought Garamond to prominence....a???e?n?
I thought this was Estienne, but that doesn't fit with 1a which I think is Cantionae Sacrae.
13a: In ecology, a small area that supports its own distinctive community: b?o?o??
11a: Wit of a dry, delicate and refined quality: a?t?c ????