12a) Large isle prepared for immune system disorders (9) ??l???i?s
2d) Proposals for U-boat assignments (11) ????e?e???r
3d) Reserve goalie is a shop proprietor (11) ????e?e???r
24d) Choose addresses in voting regions (11) ?le???r????
50d) Amused to enter date in wrongly (11) e?????????d