Excitatory and inhibitory effects of same neuron.

[Haj]

Hi, I have figured out one way in which one neuron can have an excitatory and inhibitory effect but need another way. I've googled it but not come up with anything. The way I already have is when the neuron synthesis 2 neurotransmitters of opposing effects and the effect exerted depends on the type of receptor located at the post synaptic membrane.

Does anyone know of another way please?

[Clanad]

This article describes use of brain-derived neurotrophic factor (BDNF) to alter the neurotransmitter release properties of  sympathetic neuron-myocyte connections... which in effect changed the excitatory to inhibitory cholinergic transmission...

Be sure to read Yang, et al footnote #3...

http://www.nature.com/neuro/journal/v5/n6/full/nn0602-503.html;jsessionid=8DFBBC93C9B60EAA803DF44A56E2E4FD#B3

Good luck!

[Haj]

Thank you so much for taking the time to find that article for me.

Having read the article tho, it seems this is already the way of a neuron being excitatory and inhibitory that I had already found, although I understand it much more having read the article.

I can't seem to find another way at all.

Thanks again.

[Clanad]

Haj, it could be that I've interpreted your question incorrectly.  Rather than the methodology of one neuron having the excitatory or inhibitory effect, the actual mechanism of the synapses may be what you are looiing for.  There are two main kinds... electrical and chemical. A discussion of the differing properties of both are here: http://fajerpc.magnet.fsu.edu/Education/2010/Lectures/40_Synapse.htm

Perhaps the answer to your query is a comparison of the two actions...

[Haj]

Another great site, I've book marked that one!! Many thanks.

My question specifically is 'Describe 2 ways in which the same neuron can be both Excitatory and Inhibitory'.

The same answer that I keep coming across is in this one also, but not the other way, unless of course I am misinterpreting some of the info on the sites.

I did find the answers to the next couple of questions I had there tho!!

Thanks again for taking the time to answer.

[Noweia]

Anything to do with lateral inhibition? One neurone stimulates another directly beneath it but inhibits those to either side.

It was hard to find a site that explained it properly, try this one:

http://images.google.co.uk/images?q=lateral%20inhibition &hl=en&lr=&sa=N&biw=772&tab=wi