Some inconsistencies here need clarification.
1) Malware Bytes is not anti virus software. Unless you purchased the full version it only runs on demand ie, it doesn't run all the time.
2) Your ordinary Windows Vista firewall is sufficient. Microsoft Security Suite, do you mean Microsoft Security Essentials and do you keep it up to date? This is anti virus and should run all the time.
3) Chameleon Option, whats this? As far as I came see this is a multi boot logger for pc's with multiple operating systems.
4) If J drive is connected by usb then obviously you can just unplug it and not use it. If you want to re-use it you can try to reformat the drive, but that will erase anything on it.
5) Vista Home Basic, is this 32bit or 64 bit? Does sometimes cause grief.
Microsoft Security Essentials works ok, but you must keep it up to date. I've been using it for some time without problems.