Cystic fibrosis

[little_missy]

Can someone explain to me how chloride is transported through cells in people with cystic fibrosis?

From my understanding, the channel that transports chloride is blocked or doesn't function properly - therefore there is a net movement of water into cells - causing problems in the lungs, pancreas and sweat glands. But if chloride can't be transported, how is it absorbed and manage to reach these organs in the first place?

[Peter Pedant]

No in short.

and it certainly isnt intuitive as CF was around for a long time, and no-one as far as I know said - Oh this is obviously and easily explained on chloride fluxes

I think this was reviewed in the New England journal www.nejm.org but they will almost certainly want you to pay to read it.

[little_missy]

So know one knows? - Is that what you are saying?

(Sorry, I had a problem interpreting your answer)