these are some nice posts.
It helps a bit I think if you consider what Jake is saying from a Darwinian evolutionary perspective. You were designed to from and by the interaction of matter with its environment so that you could survive by interacting with this environment in an intelligent way. You need to know about basic physics, how objects move, that the same object is bigger if closer, all that kind of stuff. You can kind of extrapolate from it and synthesize these types of knowledge to more advanced types of things. But ultimately you're in some way working with the basic types of knowledge that ensured your survival.
There may have been 'some' kind of world or space or time in some universe of some bizarre kind 'before (in a sense) the Big Bang. But you were not made for that world. So how would it ever be possible for your mind to understand it, designed, as it were, for this world.