The rail company I worked for produced all their paper handouts using Powerpoint, so Bednobs' suggestion might well be worth considering.
However, despite holding a certificate declaring my competency in Powerpoint (courtesy of free training from the same employer) it's definitely not my favoured way of producing printed literature. I'm lucky enough to have the mighty Quark Xpress (as well as Microsoft Publisher) but I still like this, which is the free 'starter' version of an excellent commercial product:
http://www.serif.com/...tware/?mc=FSSPAGEPLUS
Chris