I would strongly advise using any spyware or adware as this will open your computer up to abuse.
Assuming, you mean ANTI-spyware. Malwarebytes run once a month on your PC (or more frequently, if you have been doing something naughty) should suffice.
I prefer not to tie up resources running stuff all the time. AV ok, but checking for ad/spy abuse ? Once a week should be fine. There are a number of good ones out there including that already suggested.