OneDrive is Microsoft's cloud storage system, whereby you can back up your computer files on a remote server. You get up to 5 GB free but you have to pay a subscription for more storage space. Some people use it and love it but most people simply don't bother with it.
So do you actually want to use OneDrive or are you just getting a message about it on your computer? (If so, what are you doing when that message pops up?)
If you're actually trying to use OneDrive (after having created an account), this
might be relevant
https://www.thewindowsclub.com/fix-make-sure-onedrive-is-running-on-your-pc-then-try-again-message-on-windows-10
but, without further information, it's hard to advice you further, Henry.