Well, I don't have Sky+ but in the past when I've had a problem with sky and called up, they always try the same thing first.
Unplug the box from the mains and leave off for at least 3 minutes.
Then plug the box back into the wall and don't do anything for a minute - just leave it to sit in standby.
Then after a minute press the sky button at the top of the control. It should work then.
If it's something to do with the remote...you'll find the remote reset info here...
http://www.satcure.co.uk/tech/digicode.htm
As for programming the skyplus remote...I don't know - sorry!