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No best answer has yet been selected by alancohen. Once a best answer has been selected, it will be shown here.
For more on marking an answer as the "Best Answer", please visit our FAQ.I too use Ad-aware SE and SpyBot. Someone on AB recommended Spysubtract to for removing the Coolbar. Although I hadn't had any trouble with the Coolbar I downloaded Spysubtract anyway and ran it. It succeeded in finding threats that the other two programs had missed. All of my definition files were up-to-date and the programs were set for maximum scans.
I think the genereal answer is that some clear threats that the others don't. It is best to run a couple of different ones on your system for this reason. I now run all of the above three.
When I was looking for this type of software I Googled for some opinions and generally found that Adaware and Spybot have good reputations and are both highly recommended.
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