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No best answer has yet been selected by Potatoman. Once a best answer has been selected, it will be shown here.
For more on marking an answer as the "Best Answer", please visit our FAQ.As the project implies, Wine Is Not and Emulator (WINE). So it WON'T run slowly :
http://www.winehq.org/site/myths#slow
Have a look here to see if the application you want to run might work : http://frankscorner.org/
Also, there is a .NET runtime available called Mono which now has some support for the System.Windows.Forms namespace with the help of a Wine extension.