I suppose if one scan's the websites of the internet, particularly medical websites, then one would surely find almost surely find any sign or symptom listed as a side effect of any drug.
My answer is based on my experiences and personal contact with colleagues.
If a patient had swollen legs and ankles, then the last thing that I would attribute this sign to would be a side effect of a drug.
It could happen......it might happen......medicine is not a pure science and can fool both professional and patient alike.