This must be a debilitating condition - in an awful lot of flights I have come across at most a handful of people who were uncomfortable with flying but still flew. I once saw a documentary on irrational fears (their definition, not necessarily mine). I take it you happily travel by road and rational reasoning, along the lines that on average ten people die daily on UK roads alone, does not help (much). The programme showed different ways of suspending fear, it seemed the most consistently successful one was gradual approach to the object/concept of fear. For example, the object was placed in the next room and discussed, then at the far side of the room, then a metre or two away, then within reach, and finally touched - each taking one or more separate sessions. With flying it was first discussion, visit to an airport, visit into an open aircraft, visit to an aircraft and doors closed with engine start-up, next visit to a simulator, then taxi-ing only and finally take-off. Crucial in every case seemed to be thorough de-briefing about which aspect causes discomfort or fear. If you have flown before you possibly know what is the cause, if not you should do what you can to understand it and concentrate on desensitising yourself. Personally, I would not try to knock my brain (and whatever else) out with chemicals over just this - but then I do not suffer the problem.