I'm left-handed, but I use the Computer Mouse right-handed, and it feels like the most natural thing in the world. I couldn't throw anything right-handed, so I'd be no good at Sports.
Once, I got on the wrong side of my English Teacher in Secondary School, for atrocious handwriting, so he made me (In front of the whole Class) take a piece of Chalk in my right hand, and write my name on the board - it was so bad, you'd think I'd been trying to do it during an earthquake!
I think I'd rather type everything and print it, rather than try and learn to write with a pen in my right hand...