Human Recombinant Soluble Ace2 (Hrsace2) Shows Promise For Treating Severe Covid­19

[Chinajan]

https://www.nature.com/articles/s41392-020-00374-6

[TheChair]

oh

[Zacs-Master]

I was particularly impressed by the Schematic diagram of the renin-angiotensin system and the proposed therapeutic treatment for COVID-19 targeting SARS-CoV-2 viral entry mechanism. (Left) The receptor-binding domain (RBD) of the spike protein from SARS-CoV-2 binds to ACE2.

[Sqad]

No comment, just sheer exasperation.......BUT,as PP would say:

" Just another day on AB"

[Mamyalynne]

I'll get a nice cool compress for your brow Sqad :-)

[wolf63]

Sqad, PP - 'ooo dat den'?

[Chinajan]

Argh sorry. Forgot to add text.

Was hoping the medical bods around here might venture an opinion on whether this result might be significant or is it more likely to be a one off?

[Peter Pedant]

well you have a few
sqad as medic
the prof as researcher

You.... the virus used ACE to dock and enter the cell and then KIIIIILLLLLL it! . ACE which is what it should be for, docks much better and so why not flood the patient with soluble ACE when they are infected?

ACE binds a hundred trillion ( 20 fold) times better than the virus

and the one patient got better

so wait and see

BUT boys and gurlz if you are on an ACE inhibitor for blood pressure - make sure you still take them !

or as someone else put it
[ACE inhibitors were associated with a significantly reduced risk of COVID-19 disease (adjusted HR 0.71, 95% CI 0.67 to 0.74) but no increased risk of ICU care (adjusted HR 0.89, 95% CI 0.75 to 1.06) after adjusting for a wide range of confounders.]

and the same goes for cloppy but no effect can be shown because possibly - the patients on these are pretty crap anyway

someone asked

[Chinajan]

Thank you Mr PP.