Vaccine Effective From Date

[tiggerblue10]

Sorry if this has already been asked but once the vaccine is administered, when is it effective from? I read it's 28 days but is this after the first or second dose?

[grumpy01]

Also masks will need to be worn after the 28 days as immunity and possibility of asymptomatic infection are as yet unknown.

[Peter Pedant]

preliminary report on monoclonal here

https://www.nejm.org/doi/full/10.1056/NEJMoa2029849#:~:text=Severe%20acute%20respiratory%20syndrome%20coronavirus,ameliorate%20symptoms%2C%20and%20prevent%20hospitalization.

[theprof]

Sorry Peter, but I can't find a subheading titled as you describe after reviewing the Green Book. It's certainly not on Page 9 as far as I can see although it may be me as I was in the lab at 0615 today. I have a copy of the pdf on my desk in work.

I frequently flip through the NEJM and I've just spent a few minutes accessing the journal online via the uni. Can't see any article to that effect but let's be honest here, you and I both know how peer-reviewed journals work so I wouldn't rely on it.

I and my learned colleagues do indeed like what we are seeing about the potential use of mAbs for use against this pathogen. If the editorial board or contributers to NEJM over the pond consider otherwise they are entitled to their opinion. As I said earlier, time will tell.

[theprof]

My apologies Peter. I didn't go as far back as that issue.

I do usually try to be as non-technical as I can here on AB but as you've raised this point, I'll explain.

LY-Cov555 has undergone trials in the UK prior to the trial discussed in the NEJM journal and we came to a similar conclusion. An article on the UK trial is scheduled for publication in a UK academic journal early in the new year.

Regretfully, I'm not at liberty to provide further information on this matter as I personally played a part in reviewing the more detailed article following submission to the journal and I'm contracted not to discuss it.

So essentially, we have dismissed LY-CoV555 just like our colleagues. However, the particular mAbs we are looking at right now are far more promising with three of clinical trial potential. Let me conclude by saying that LY-CoV555 is not the only mAbs that has been dismissed.

These matters are often a race between countries but as usual, the more participants, the faster we will reach our goal.

[theprof]

grumpy01, you are absolutely right. Asymptomatic transmission remains a very real danger. Extensive research into transmission continues to be needed as we have relatively little knowledge of it right now. The possibility of mutation also remains a matter of concern.

[ukanonymous]

I yhink yhe facial paralysis and fake hiv positive reults happens within days. Rna vaccimes have not been thoroughly tested yet. I wouldnt want anyone i know to take it :(

[ukanonymous]

DNA –> RNA –> protein (aka the virus’ weapon against the cell). mRNA won’t enter the nucleus. They interact with cell structures only in cytoplasm, outside nucleus. Of course, this begs the question: why won’t foreign mRNA agents be killed by the body before they can enter our protein making factories?

[ukanonymous]

Ps im not anti vaxer just not 5aking this one. Some5hing doesnt feel right to me about it.

[bobbinwales]

But you dont know what. ? Gut instinct over science? Not to worry there will be tens of millions who are happy to have your shots and get a bit nearer to normallity.
3000 deaths in USA yesterday, scarey.