Mary Shelley's mother was Mary Wolstencraft. An outspoken advocate for womens rights (admittedly only for middle class women). If I'm rememboring correctly Mary Wolstencraft died giving birth to Mary Shelley which is something she blamed herself for her whole life. William Godwin was Mary's father, a deeply intelligent, well written man. She may well have felt that she could not compare to him and that she robbed him of the one person he really loved... her mother. This is heresay naturally.
Basically, one theory on the novel Frankenstein goes is that Mary Shelley is actually represented as all the characters in this novel, especailly the monster. She was also a very liberal woman for her time and had a fair few love affairs along with the possibility of dabbling in some rather strong substances.
The monster in the novel only ever looks for love. It has more understanding and knowledge than many 'normal' human beings but no one ever looks below the surface and it has an anger that can not be controlled. Plus it views itself unsympathetically and is tied forever to Frankenstein.
Frankenstein is devastated by the death of his mother and spends his whole life trying to make ammends, he wants to cheat death and bring order. However he only ever brings chaos.
You could go as far to say that Frankenstein and the monster are actually two parts of the same character. One struggling to come to terms with death and the chaos he caused, the other always feeling like an outcast and with an anger at the world. The real question is my head is who is actually the monster.
Apologies for the spelling but it is Sunday morning. If you do some googling with the information I've given you I think you will find out rather a lot more about the book.
Hope that helps in some way.