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For more on marking an answer as the "Best Answer", please visit our FAQ.You can do it in a little over 3 days if you have 2 drivers. I know that sounds absurd but I have done it. My sister and I drove from San Francisco to New York in a few hours over 3 days. Another time we managed to drive from San Francisco to New York to Boston to Chicago and back to San Francisco in 10 days. It wasn't a lot of fun, but we had specific goals in mind; the number one being time frames. The person posting this question may just be arriving in New York and need to get to San Francisco as quickly as possible. 3 Days and a few hours if you're traveling in good weather and there is no major construction on the interstate system.