I use Mailwasher Pro because I have 21 e-mail addresses. It's great, but I can't offer any particular advice, just general stuff. First thing in the morning I always check mail, ignore everything that it says is known spam, flick through the rest, add any to my friends list that I notice (it imports your contacts form OE as friends, but I don't use OE). Then I process mail. I then do another mail-check and anopther process as for some reason, first thing in the morning there seems to be a second batch of junk just waiting there. Then I collect my mail. If you're on broadband, you can just set it to check periodically, but always collect your mail imediately after a check/process, other wise you'll get junk that appears in the interim.