Are you in a hurry? From Calais at 7.30 in the morning, on a sunday it is possible to be across the Spanish border by 7.00pm in the evening, via A26,A1,A10,A63,N10 to hondarribia, for a first stop in San Sebastian, then an early start next day would get you to somewhere between Madrid and Jaen following the A8 to Bilbao,A68 to Burgos, then the E5 as far as Bailen/Linares, then the N323 to Granada and the newly named A44 to Malaga. The advantage with doing France on a Sunday is NO LORRIES and if you drive at night in spain, the heavy stuff is mostly off the road after dusk/7pm.We travel to Spain and Italy quite often, and out of the many routes we,ve tried, this IS the fastest from Calais. Another fast route is from the ferryport at Caen(Portsmouth-Caen) via N158,N138 to Alencon, then the A28 to Le Mans,and on towards Tours.As of last year the A28 was not finished and only extended to about 20km from Tours,leaving a section of non-dualled N138 before joining the A10.This route can have a lot of traffic and early in the morning fog can be a real problem between Caen and Le Mans. Good luck anyway.