Hereditary intolerance

shane watson | 16:41 Wed 06th Feb 2008 | Education

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Can anyone give more information on hereditary fructose intolerance and how the hereditary intolerance is produces. What is the role of enzymes in hereditary intolerance?
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mathewsincla

Hereditary fructose intolerance is produced due to a deficiency of the enzyme, aldolase B that cleaves fructose 1-phosphate, which is formed from fructose by the action of fructokinase, to dihydroxyacetone phosphate and D-glyceraldehyde. Due to the deficiency of the enzyme, fructose 1-PO4 accumulates in cells and causes hepatic and renal damage.
http://www.healthknow.info/genetic_disorders.a sp

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