I just got back from there a couple of weeks ago! Century 21 department store-its downtown-you get off the number 1 subway line at Rector street and its a couple of streets away beside Ground Zero. Its amazing for handbags as it has got all the big labels but at discount prices! I got a Guess handbag for $55! Its a bit like Primark on a Saturday though-eg crowded, but if you can push your way through the crowds, you're sure to find a bargain! - www.c21stores.com
Also, around Macy's at 34th street there are some good shops like Gap, American Eagle, Forever 21. Macy's itself is good for clothes and shoes as well.
Have fun-and take a big suitcase!