19a Animal disease whose spores can be weaponised? (7)
21a City in the South of France, the chief town of Languedoc? (11)
27a 21-inch plug and socket audiovisual connection? (5)
41a Seat of Government in Holland? (3,5)
43a Apparent change of frequency in a wave due to relative motion? (7,6)
39d 2001's sentinent computer? (3)
40d Metal with atomic number? (4)