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Hangover
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For more on marking an answer as the "Best Answer", please visit our FAQ.Firstly, alcohol upsets your body's water balance, so you become dehydrated - side effect of dehydration... headache.
Second, when alcohol is metabolized, it causes your blood to become more acidic than normal (this is called acidosis) which can cause tinnitus, blurred vision, vertigo, visual disturbances, photophobia (turn that god damn light off!) nausea, vomiting, abdominal pain and diarrhea.
Third, alcohol alters the normal daily rhythm of certain body functions including your sleeping and dietary patterns.
Fourth, alcoholic drinks contain certain impurities called congeners which can be toxic (I understand that the manufacturers of Skyy vodka claim to remove all of these)
So simply by drinking a drink with fewer congeners in does not mean you will not get a hang over. Combining this with drinking drinks with a high water content, or alternating alcoholic drinks with water plus that most dreaded of words...moderation. Chin chin!