may be your sound drivers are not working properly .
or the sound drivers are conflicting with some other software due to which sound gets disrupted .
or the speakers wire will be loose so the signals are not properly forwarded.
so update the sound drivers from the device manager.
sound tab should not be muted..
speaker would be connected to the power supply and the computer.
power should be on.
finally check the sound cable.
for further assistance you can approach at this source at
http://www.iyogi.co.uk/setup-install.html