One to finish, 28a - Afflicted, become ill without treatment recommended initially (8) s?r?c?e? stricken appears to fit etc. but cannot fathom out how or why.
Thanks once again Kayakamina, could see sicken but not the tr. I'm new to cryptic crosswords (finishing them that is) and have not as yet sussed out the nuances in the clues, I will get there, hopefully.