By motherboard i assume you mean the desktop PC. Your usb lazer mouse is either wired or wireless but whichever it is the usb plug at the end of the wired version or the usb wireless receiver for the wireless version has to be plugged into your laptop or your desktop PC. It cannot connect to both at the same time which from the wording of your question is what i think you were expecting. If this is not the case could you be more clear i.e. you plugged the mouse into your desktop PC and it was not recognised or no driver was installed etc. etc.
regards GARFIELD